uk_biobank:phenotype_request
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uk_biobank:phenotype_request [2016/04/08 11:51] brooke_huibregtse |
uk_biobank:phenotype_request [2016/06/09 22:35] (current) brooke_huibregtse |
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| **The research question you are planning to answer with the variables above:** | **The research question you are planning to answer with the variables above:** | ||
| - | Some measures of sexual behavior, including age of sexual initiation and lifetime number of partners, are risk factors for acquiring sexually transmitted infections, human immunodeficiency virus (HIV), and externalizing psychopathology such as drug use. Same sex partnerships correspond to differential risk for infection, due to varying rates of transmission across types of sex acts as well as population differences in prevalence of infection. Twin and family studies have demonstrated moderate heritabilites for a range of sexual behaviors, few studies have tested the extent to which these trait heritabilities are polygenic or tagged by common variants. | + | Some measures of sexual behavior, including age of sexual initiation and lifetime number of partners, are risk factors for acquiring sexually transmitted infections, human immunodeficiency virus (HIV), and externalizing psychopathology such as drug use. Same sex partnerships correspond to differential risk for infection, due to varying rates of transmission across types of sex acts as well as population differences in prevalence of infection. Twin and family studies have demonstrated moderate heritabilites for a range of sexual behaviors, few studies have tested the extent to which these trait heritabilities are polygenic or tagged by common variants. |
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| **The variable name, link to the variable, and Field ID for EACH variable, listed below:** | **The variable name, link to the variable, and Field ID for EACH variable, listed below:** | ||
| - | 1. Home area population density | + | 1. Home area population density http:// |
| - | 2. Length of time at current address | + | 2. Length of time at current address http:// |
| - | 3. Own or rent accommodation lived in - http:// | + | 3. Own or rent accommodation lived in http:// |
| - | 4. Type of accommodation lived in - http:// | + | 4. Type of accommodation lived in http:// |
| - | 5. Current employment status | + | 5. Current employment status http:// |
| - | 6. Time employed in main current job - http:// | + | 6. Time employed in main current job http:// |
| The research question you are planning to answer with the variables above: | The research question you are planning to answer with the variables above: | ||
| We are interested in doing a runs of homozygosity analysis in the UK Biobank data, assessing the relationship between these sociodemographic variables and autozygosity. Based on previous research and the ROH literature, we have reason to believe that various sociodemographic confounders can subtly bias the relationship between very distant inbreeding and psychiatric traits of interest, but many of our case-control datasets do not have these confounding variables measured, making it difficult to test the direction and strength of their influence. The variables listed above will allow us to test whether things like urban/rural location, education, employment, and other SES measures influence autozygosity and therefore could be influencing our ROH-psychiatric analyses. | We are interested in doing a runs of homozygosity analysis in the UK Biobank data, assessing the relationship between these sociodemographic variables and autozygosity. Based on previous research and the ROH literature, we have reason to believe that various sociodemographic confounders can subtly bias the relationship between very distant inbreeding and psychiatric traits of interest, but many of our case-control datasets do not have these confounding variables measured, making it difficult to test the direction and strength of their influence. The variables listed above will allow us to test whether things like urban/rural location, education, employment, and other SES measures influence autozygosity and therefore could be influencing our ROH-psychiatric analyses. | ||
uk_biobank/phenotype_request.1460137890.txt.gz ยท Last modified: 2016/04/08 11:51 by brooke_huibregtse
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