Dr. Andrew Smolen

PUBLICATIONS

Ehringer, M.A., Clegg, H.V., Collins, A.C., Corley, R.P., Crowley, T.J., . Hewitt, J.K, Hopfer, C.J., . Krauter, K, Lessem, J., Rhee, S.H., Schlaepfer, I., Smolen, A., Stallings, M.C., Young, S.E., Zeiger, J.S. Association of the Neuronal Nicotinic Receptor b2 Subunit Gene (CHRNB2) with Subjective Responses to Alcohol and Nicotine. Neuropsychiatric Genetics. (2007) PUBMED abstract

Haberstick B.C., Timberlake D., Ehringer M.A., Lessem J.M., Hopfer C.J., Smolen A., Hewitt J.K.Genes, time to first cigarette and nicotine dependence in a general population sample of young adults. Addiction. (2007). Pubmed Abstract

Young, S.E., Smolen, A., Hewitt, J.K., Haberstick, B.C., Stallings, M.C., Corley, R.C. and Crowley, T.J. Interaction Between MAO-A Genotype and Maltreatment in the Risk for Conduct Disorder: Failure to Confirm in Adolescent Patients. Am. J. Psych, 163(6), 1019-25 (2006). Pubmed Abstract

Timberlake D.S., Rhee S.H., Haberstick B.C., Hopfer C., Ehringer M., Lessem J.M., Smolen A., Hewitt J.K. The moderating effects of religiosity on the genetic and environmental determinants of smoking initiation. Nicotine Tob Res., 8(1), 123-33. (2006). Pubmed Abstract

Timberlake, D.S., Haberstick, B.C., Lessem, J.M., Smolen, A. Ehringer, M.A., Hewitt, J.K. and Hopfer, C. An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health. Health Psychol, 25(2), 190-197. (2006). Pubmed Abstract

Sakai, J.T., Young, S.E., Stallings, M.C., Timberlake, D., Smolen, A., Stetler, G.L., Crowley, T.J. Case-control and within-family tests for an association between conduct disorder and 5HTT-LPR. American Journal of Medical Genetics - Neuropsychiatric Genetics, 141(8), 825-832 (2006).

Sakai, J.T., Hopfer, C.J., Hartman, C., Haberstick, B.C., Smolen, A., Corley, R.P., Stallings, M.C., Young, S.E., Timberlake, D., Hewitt, J.K., Crowley, T.J.  Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems. Drug and Alcohol Dependence, (2006). PUBMED abstract 

Lessem, JM., Hopfer, CJ., Haberstick, BC., Timberlake, D., Ehringer, MA., Smolen, A., Hewitt, JK. Relationship between adolescent marijuana use and young adult illicit drug use.  Behavior Genetics, 36(4), 498-506. (2006).  PUBMED abstract 

Huizinga D., Haberstick B.C., Smolen A., Menard S., Young S.E., Corley R.P., Stallings M.C., Grotpeter J., Hewitt J.K. Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype.Biol Psychiatry, 60(7), 677-83. (2006). Pubmed Abstract

Hopfer, C.J., Lessem, J.M., Hartman, C.A., Stallings, M.C., Cherny, S.S., Corley, R.P., Hewitt, J.K., Krauter, K.S., Mikulich-Gilbertson, S.K., Rhee, S.H., Smolen, A., Young, S.E., Crowley, T.J. . A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9. Drug and Alcohol Dependence, (2006). PUBMED abstract 

Hopfer, C.J., Young, S.E., Purcell, S., Crowley, T.J., Stallings, M.C., Corley, R.P., Rhee, S.H., Smolen, A., Krauter, K., Hewitt, J.K., Ehringer, M.A. Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. American Journal of Medical Genetics ­ Neuropsychiatric Genetics, 141(8), 895-901. (2006). PUBMED abstract 

Harris K.M., Halpern C.T., Smolen A., Haberstick B.C.The National Longitudinal Study of Adolescent Health (Add Health) twin data. Twin Res Hum Genet., 9(6), 988-97 (2006). Pubmed Abstract

Haberstick, B.C., Smolen, A. and Hewitt, J.K. Family-based association test of a promoter polymorphism in the serotonin transporter and aggressive behavior in a general population sample of children. Biological Psychiatry, 59(9), 836-843 (2006). Pubmed Abstract

Hopfer, C.J., Timberlake, D.S., Haberstick, B.C., Lessem, J.M., Ehringer, M.A., Smolen, A. and Hewitt, J.K. Genetic Influences on Quantity of Alcohol Consumed by Adolescents and Young Adults. Drug and Alcohol Dependence, 78, 187-193 (2005).

Haberstick, B.C., Lessem, J.M., Hopfer, C.J., Smolen, A., Ehringer, M.A., Timberlake, D., and Hewitt, J.K. MAOA Genotype and Antisocial Behaviors in the Presence of Childhood and Adolescent Maltreatment. American Journal of Human Genetics (Neuropsychiatric Genetics) 135B: 59-64 (2005). Pubmed Abstract

Stallings, M.C., Corley, R.C., Dennehey, B., Hewitt, J.K., Krauter, K.S., Lessem, J.L., Mikulich-Gilbertson,S.K., Rhee, S.H., Smolen, A., Young, S.E. and Crowley, T.J. A genome-wide search for quantitative trait loci influencing antisocial drug dependence in adolescence. Archives of General Psychiatry, 62, 1042-1051. (2005) PUBMED abstract

Haberstick, B.C. and Smolen, A. Genotyping of three single nucleotide polymorphisms following whole genome preamplification of DNA collected from buccal cells. Behavior Genetics, 34: 541-547 (2004). Pubmed Abstract

Anchordoquy, H. C., McGeary, C., Liu, L., Krauter, K.S. and Smolen, A. Genotyping of three candidate genes following whole genome preamplification preamplification of DNA collected from buccal cells.Behavior Genetics 33: 73-78 (2003).

Loo, S.K., Specter, E., Smolen, A., Hopfer, C., Teale, P.D. and Reite, M.L. Functional effects of the DAT1 polymorphism on EEG measures in ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 42: 987-993 (2003). Pubmed Abstract

Stallings, M.C., Corley, R.C., Hewitt, J.K., Krauter, K.S., Lessem, J.L., Mikulich, S.K., Rhee, S.H., Smolen, A., Young, S.E. and Crowley, T.J. A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. Drug and Alcohol Dependence, 70: 295-307 (2003). Pubmed Abstract

Young, S.E., Smolen, A., Stallings, M.C., Corley, R.P. and Hewitt, J.K. Sibling-based association analyses of the serotonin transporter polymorphism and internalizing behavior problems in children. Journal of Child Psychology and Psychiatry, 44: 1-7 (2003). Pubmed Abstract

Hutchison, K.E, LaChance, H., Niaura, R., Bryan, A. D. and Smolen, A. The DRD4 VNTR polymorphism influences reactivity to smoking cues. Journal of Abnormal Psychology 11: 134-143 (2002). Pubmed Abstract

Hutchison, K.E., McGeary, J., Smolen, A., and Bryan, A.D. The DRD4 Polymorphism Moderates Craving After Alcohol Consumption. Health Psychology 21: 139-146 (2002). Pubmed Abstract

Hutchison, K.E., LaChance, H.A., Bryan, A.D., McGeary, J. and Smolen, A. Personality Factors and the DRD4 Polymorphism Moderate the Effects of a Motivational Intervention to Reduce Hazardous Drinking. Submitted.

Young, S.E., Smolen, A., Corley, R.P., Krauter, K.S., DeFries, J.C., Crowley, T.C. and Hewitt, J.K. Dopamine Transporter Polymorphism is Associated with Childhood Externalizing Behavior. American Journal of Medical Genetics (Neuropsychiatric Genetics) 114: 144-149 (2002). Pubmed Abstract

van de Kamp, J.L. and Smolen, A. Relationships Between Pregnancy and Vitamin B-6 Nutriture on Brain 3-Hydroxykynurenine Concentrations in Mice. Nutritional Neuroscience 3: 131-138 (2000).

Westrick, J.A., Johnson, C.R., Simmons, J.H. and Smolen, A. Shifts in Affinity and Enthalpy of Oxygen Binding to Human Hemoglobin A Induce by Pyridoxal and Pyridoxal 5'-phosphate. Journal of Nutritional Biochemistry 8: 20-24 (1997).

Morale, R.P., Smolen, T.N. and Smolen, A. Relationships Between Pregnancy and Vitamin B-6 Nutriture on Hepatic Tryptophan 2,3-Dioxygenase Activity in Mice. Nutrition Research 16: 851-854 (1996).

van de Kamp, J.L. and Smolen, A. Response of Kynurenine Pathway Enzymes to Pregnancy and Dietary Level of Vitamin B-6. Pharmacology Biochemistry and Behavior 51: 753-758 (1995).

van de Kamp, J.L., Westrick, J.A. and Smolen, A. B-6 Vitamer Concentrations in Mouse Plasma, Erythrocytes and Tissues. Nutrition Research 15: 415-422 (1995).

Smolen, A. Vitamin B-6 Metabolism and the Maternal-Fetal Relationship. In: Vitamin B-6 in Pregnancy, Lactation and Infancy, Raiten, D., ed. CRC Press, Boca Raton, FL., 1995, pp. 93-108.

Westrick, J.A. and Smolen, A. Aminotransferase Activities in Mouse, Mus Domesticus, Erythrocytes Separated According to Age. Comparative Biochemistry and Physiology 109B: 489-497 (1994).

Smolen, A., Marks, M.J., DeFries, J.C. and Henderson, N.D. Individual Differences in Sensistivity to Nicotine in Mice: Response to Six Generations of Selective Breeding. Pharmacology Biochemistry and Behavior 49: 531-540 (1994).

Smolen, A., Smolen, T.N. and Han, P.C. Alterations in Regional Brain GABA Concentration and Turnover During Pregnancy. Pharmacology Biochemistry and Behavior 44: 63-69 (1992).

Smolen, A. and Marks, M.J. Genetic Selections for Nicotine and Cocaine Sensitivity in Mice. Journal of Addictive Diseases 10: 7-28 (1991).

Smolen, A., Eckerson, H.W., Gan, K., Hailat, N. and La Du, B.N. Characteristics of the Genetically Determined Allozymic Forms of Human Serum Paraoxonase/Arylesterase. Drug Metabolism and Disposition. 19: 107- 112 (1991).

Gan, K., Smolen, A., Eckerson, H.W. and La Du, B.N. Purification of Human Serum Paraoxonase/Arylesterase. Evidence for One Esterase Catalyzing Both Activities. Drug Metabolism and Disposition 19: 100-106 (1991).

Smolen, T.N. and Smolen, A. Purinergic Modulation of Ethanol-Induced Sleep Time in Long-Sleep and Short-Sleep Mice. Alcohol 8: 123-130 (1991).

Leibman, D., Smolen, A. and Smolen, T.N. Strain, Sex and Developmental Profiles of Cocaine Metabolizing Enzymes in Mice. Pharmacology Biochemistry and Behavior 37: 161-165 (1990).

Furth-Walker, D., Leibman, D. and Smolen, A. Relationship Between Blood, Liver and Brain Pyridoxal Phosphate and Pyridoxamine Phosphate Concentrations in Mice. Journal of Nutrition 120: 1338-1343 (1990).

Smolen, T.N. and Smolen, A. Developmental Expression of Cocaine Hepatotoxicity in the Mouse. Pharmacology Biochemistry and Behavior 36: 333-338 (1990).

Leibman, D., Furth-Walker, D. and Smolen, A. Vitamin B-6 Metabolic Enzymes in Blood and Placenta of Pregnant Mice. Journal of Nutrition 120: 178-184 (1990).

Smolen, T.N., Smolen, A. and van de Kamp, J.L. Developmental Profile of Hepatic Alcohol and Aldehyde Dehydrogenase Activities in Long-Sleep and Short-Sleep Mice. Alcohol 7: 69-74 (1990).

Leibman, D., Furth-Walker, D. Smolen, T.N. and Smolen, A. Pyridoxal 5'- phosphate and Pyridoxamine 5'-phosphate Concentrations in Blood and Tissues of Mice Fed Ethanol-Containing Liquid Diets. Alcohol 7: 61-68 (1990).

Smolen, A. and Smolen, T.N. Reproducibility of Ethanol Elimination Rates in Long-Sleep and Short-Sleep Mice. Journal of Studies on Alcohol. 50: 519- 524 (1989).

Furth-Walker, D., Leibman, D. and Smolen, A. Changes in Pyridoxal Phosphate and Pyridoxamine Phosphate in Blood, Liver and Brain in the Pregnant Mouse. Journal of Nutrition 119: 750-756 (1989).

Smolen, T.N. and Smolen, A. Blood and brain ethanol concentrations at the time of loss of righting response in long sleep and short sleep mice. Alcohol 6: 33-38 (1989).

Smolen, T.N., Smolen, A. and van de Kamp, J.L. Developmental Profile of Alcohol and Aldehyde Dehydrogenases in Long Sleep and Short Sleep Mice. Annals of the New York Academy of Science 492: 66-68 (1987).

Wehner, J.M., Murphy-Erdosh, C., Smolen, A. and Smolen, T.N. Genetic Variation in Paraoxonase Activity and Sensitivity to Diisopropylphosphofluoridate in Inbred Mice. Pharmacology Biochemistry and Behavior 28: 317-320 (1987).

Baker, R.C, Smolen, A., Smolen, T. N. and Deitrich, R.A. Relationship Between Acute Ethanol Related Responses in Long-Sleep and Short-Sleep Mice. Alcoholism: Clinical and Experimental Research: 11: 574-578 (1987).

Smolen, A., Smolen, T.N., Han P.C. and Collins, A.C. Sex Differences in the Recovery of Brain Acetylcholinesterase Activity Following a Single Exposure to DFP. Pharmacology Biochemistry and Behavior 26: 813-820 (1987).

Smolen, A., Smolen, T. N. and van de Kamp, J.L. Alterations in Brain Catecholamines During Pregnancy. Pharmacology Biochemistry and Behavior 26: 613-618 (1987).

Smolen, A., Smolen, T.N. and van de Kamp, J.L. Sensitivity of Inbred and Selectively Bred Mice to Ethanol. Alcohol 4: 57-62 (1987).

Smolen, A. and Smolen, T.N. Demonstration of a Threshold Concentration for Ethanol at the Time of Regaining the Righting Response in Long-Sleep and Short-Sleep Mice. Alcohol and Drug Research 7: 279-283 (1987).

Collins, A.C., Smolen, T.N., Smolen, A. and Medhurst, L.J. Cross Tolerance Between Muscarinic Agonists: Role of Muscarinic Receptors. Pharmacology Biochemistry and Behavior 26: 173-182 (1987).

Smolen, T.N., Smolen, A. and Collins, A.C. Dissociation of Decreased Numbers of Muscarinic Receptors from Tolerance to DFP. Pharmacology Biochemistry and Behavior 25: 1293-1301 (1986).

Smolen, A. and Smolen, T.N. Genetic Influence on Increased Seizure Susceptibility in Pregnancy. Life Sciences 39: 1525-1530 (1986).

Smolen, A., Smolen, T.N. and van de Kamp, J.L. Effect of Naloxone Administration on Pregnancy-Associated Seizures. Life Sciences 38: 1899-1905 (1986).

Smolen, A., Marks, M.J., Smolen, T.N. and Collins, A.C. Dose and Route of Administration Alter the Relative Elimination of Ethanol by LS and SS Mice. Alcoholism: Clinical and Experimental Research 10: 198-204 (1986).

Smolen, A., Smolen, T.N., Oh E.I. and Collins, A.C. A Strain Comparison of Physiological and Locomotor Responses of Mice to Diisopropylfluorophosphate. Pharmacology Biochemistry and Behavior 24: 1077-1082 (1986).

Wehner, J.M., Smolen, A. and Smolen, T.N. Recovery of Acetylcholinesterase Activity After Acute Organophosphate Treatment of CNS Reaggregate Cultures. Fundamental and Applied Toxicology 5: 1104-1109 (1985).

Smolen, A., Smolen, T.N., Wehner, J.M. and Collins, A.C. Genetically Determined Differences in Acute Responses to Diisopropylfluorophosphate. Pharmacology Biochemistry and Behavior 22: 623-630 (1985).

Marks, M.J., Smolen, A. and Collins, A.C. Brain NaKATPases in Mice Differentially Sensitive to Alcohols. Alcoholism: Clinical and Experimental Research 8: 390-396 (1984).

Collins, A.C., Smolen, A., Wayman, A.L. and Marks, M.J. Ethanol and Temperature Effects of Five Membrane-bound Enzymes. Alcohol 1: 237-246 (1984).

Smolen, A., Smolen, T.N. and Collins, A.C. Seizure Susceptibility of the Pregnant Mouse. Pharmacology Biochemistry and Behavior 17: 91-97 (1982).

Smolen, A., Smolen, T.,N. and Collins, A.C. The Effect of Age, Sex and Genotype on the Subcellular Distribution of Aldehyde Dehydrogenase Activity in the Mouse. Comparative Biochemistry and Physiology 73B: 815-822 (1982).

Smolen, A., Wayman, A., Smolen, T.N., Petersen, D.R. and Collins, A.C. Subcellular Distribution of Hepatic Aldehyde Dehydrogenase Activity in Four Inbred Mouse Strains. Comparative Biochemistry and Physiology 69C: 199-204 (1981).

Smolen, A., Petersen, D.R. and Collins, A.C. Liver Cytosolic Aldehyde Dehydrogenase Activity in the pregnant Mouse. Developmental Pharmacology and Therapeutics 3: 31-49 (1981).

Smolen, A., Atkinson, N. and Petersen, D.R. The role of Cytosolic Aldehyde Dehydrogenase in Ethanol Metabolism in DBA and C57BL Mice. In: Alcohol and Aldehyde Metabolizing Systems, Vol 4 (Edited by Thurman, R.G.), pp. 627- 634, Plenum Press, New York, 1980.

Smolen, A. and Anderson, A.D. Partial Purification and Characterization of a Reduced Nicotinamide Adenine Dinucleotide-linked Aldehyde Reductase from Heart. Biochemical Pharmacology 25: 317-323 (1976).

REPRESENTATIVE PAPERS PRESENTED AT SCIENTIFIC MEETINGS:

Smolen, T.N., Smolen, A. and Willcutt, E. Catechol-O-methyltransferase polymorphism in ADHD.
Behavior Genetics Association, 2004.

Cosgrove, V.E., Buhlig, B., Rhee, S.H., Young, S.E., Smolen, A., Corley, R.P. and Hewitt, J.K.
Sibling-based association analyses of the serotonin transporter polymorphism and Generalized Anxiety Disorder in adolescents.
Behavior Genetics Association, 2004.

Hopfer, C.J., Timberlake, D., Haberstick, B., Lessem, J.M., Ehringer, M.A., Smolen, A. and Hewitt, J.K.
Genetic Influences on Quantity of Alcohol Consumed by Adolescents and Young Adults.
College on Problems of Drug Dependence, 2004.

Corley, R.P., Young, S.E., Stallings, M. C., Hewitt, J.K., Smolen, A. and Huizinga, D.
Sibling resemblance for adolescent problem behavior: National Youth Survey and CADD.
Behavior Genetics Association, 2003.

Lessem, J.M., Hopfer, C., Smolen, A. and Hewitt, J.K.
Genetic Analysis of Antisocial Behavior and Drug Abuse in the Add Health Study.
Behavior Genetics Association, 2003.

M. C. Stallings, M.C., Corley, R. P., Hewitt, J. K., Krauter, K. S., Lessem, J. M., Mikulich, S.K., Rhee, S.H., Smolen, A., Young, S.E. and Crowley, T.J.
A genome-wide search for quantitative trait loci influencing substance dependence vulnerability.
College on Problems of Drug Dependence, 2002.

Smolen, A., Anchordoquoy, H. C., McGeary, C., Liu, L. and Krauter, K.S.“Genotyping of three candidate genes following whole genome preamplification of DNA collected from buccal cells.”
Behavior Genetics Association, 2002.

Hutchison, K.E., LaChance, H., Bryan, A.D., McGeary, J. and Smolen, A.
“Moderation of the Effects of a Motivational Intervention to Reduce Drinking by Inpulsivity/Sensation Seeking and the D4 Receptor Gene.”
Research Society on Alcoholism, 2000.

Smith, S.D., Pennington, B.F., Willcutt, E., Deffenbacher, K., D. Hoover, D., Smolen, A., Moyzis, R., Olson, R.K. and DeFries, J.C.
“Linkage of an ADHD Phenotype to 6p21.3 in a Population with Reading Disability.”
American Society for Human Genetics, 2000.

Young, S.E., Smolen, A., Corley, R.P., Stallings, M.C. and Hewitt, J.K.
“Evidence of Association Between Externalizing Behavior and Dopamine Transporter Genotype in Young Twins.”
Behavior Genetics Association, 2000.