uk_biobank:downloading_the_data
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uk_biobank:downloading_the_data [2016/02/19 15:49] lessem |
uk_biobank:downloading_the_data [2016/03/15 12:09] luke /* Quality Control */ |
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| - | These procedures were all derived from the [[http:// | + | These procedures were all derived from the [[http:// |
| Line 10: | Line 10: | ||
| - The key, k1234.key was saved from the PI's email. | - The key, k1234.key was saved from the PI's email. | ||
| - This command was run to decrypt the downloaded phenotype file | - This command was run to decrypt the downloaded phenotype file | ||
| - | < | + | |
| $ ./ | $ ./ | ||
| - | </ | + | |
| which produced the file ukb1234.enc_ukb | which produced the file ukb1234.enc_ukb | ||
| - Once decrypted, the following commands were run to extract the data into useful formats | - Once decrypted, the following commands were run to extract the data into useful formats | ||
| - | < | + | |
| $ ./ukb_conv ukb1234.enc_ukb bulk -eencoding.ukb | $ ./ukb_conv ukb1234.enc_ukb bulk -eencoding.ukb | ||
| $ ./ukb_conv ukb1234.enc_ukb docs -eencoding.ukb | $ ./ukb_conv ukb1234.enc_ukb docs -eencoding.ukb | ||
| $ ./ukb_conv ukb1234.enc_ukb r -eencoding.ukb | $ ./ukb_conv ukb1234.enc_ukb r -eencoding.ukb | ||
| - | </ | + | |
| - bulk is a list of IDs for use with the ukbfetch utility | - bulk is a list of IDs for use with the ukbfetch utility | ||
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| + | |||
| + | - Genetic data is downloaded following the instructions at [[http:// | ||
| + | - Scripted downloads of all chromosomes were done using a command such as | ||
| + | |||
| + | $ seq 1 26 | parallel -j1 ./gfetch cal {} | ||
| + | $ seq 1 26 | parallel -j1 ./gfetch imp {} | ||
| + | |||
| + | - A single sample map (impv1.sample) for the imputed data also was downloaded | ||
| + | |||
| + | $ ./gfetch imp 1 -m | ||
| + | |||
| + | |||
| + | |||
| + | |||
| + | ====== Quality Control ====== | ||
| + | We identified lists of individuals and positions to exclude from information in the UKB data and in the Axiom Array unimputed genotypes. | ||
| + | - All files can be found on RC at: / | ||
| + | - UKB and Affymetrix performed a number of QC analyses to exclude questionable positions and identify individual samples. Additional pdfs from the UKBiobank are found within / | ||
| + | - Additional Affymetrix and UKB information can be found on their websites: | ||
| + | [[http:// | ||
| + | - A list of 1068 individuals to exclude is in Exclude_individuals.poorQC.UKB_Affy_sex.id on RC. | ||
| + | - A list of 8010 positions to exclude is in duplicate.positions.excludesnps.txt on RC. | ||
| + | - A README.txt file located on RC contains the steps used and additional information. | ||
uk_biobank/downloading_the_data.txt ยท Last modified: 2020/04/22 11:35 by luev6784
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