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lab_1 [2017/04/13 13:43]
scott /* Example commands */
lab_1 [2017/04/25 10:49] (current)
scott /* Lab 1 Assignment */
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 ### Question 1 (4 points) ### Question 1 (4 points)
 ### a) What does "positive strand" mean in the header of the genotype file? ### a) What does "positive strand" mean in the header of the genotype file?
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 ### Question 2 (2 points) ### Question 2 (2 points)
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 ###    the website  http://popgen.uchicago.edu/ggv/ ###    the website  http://popgen.uchicago.edu/ggv/
  
 +
 +Example full credit answers:
 +  - Question 1
 +    - "The positive strand refers to the leading strand of DNA being sequenced (eg. the strand that RNA would be replicated against)."
 +    - "Each DNA strand is a double helix - it has two strands. The first strand given is the postive strand; the second strand is based on the first and is called the negative strand. For example, if the positive strand is ATCGG, then the negative strand is TAGCC (T always pairs with A, and G always pairs with C). The header is stating that the genome provided is only based on the first strand (the positive strand)."
 +  - Question 2
 +    - awk '{print $2}' hu916767_20170324191934.txt
 +    - cut -f2 hu916767_20170324191934.txt
 +  - Question 3
 +    - awk '{print $2}' hu916767_20170324191934.txt | sort -u
 +    - cut -f2 hu916767_20170324191934.txt | sort -u
 +    - The command extracts the second column from a tab-delimited file, alphanumerically sorts it, and removes all duplicate lines.
 +  - Question 4
 +    - grep 'rs671' hu916767_20170324191934.txt
 +    - Output: rs671 12 112241766 GG
 +    - "Interpretation: This individual does not flush, has a normal risk for alcoholism, normal risk of esophageal cancer, and Disulfiram is effective for alcoholism for this individual."
 +  - Question 5
 +    - Minor allele is A in individuals of European ancestry and MAF is .36
 +    - In individuals of African ancestry MAF is .021
 +    - The SNP is associated with thinking cilantro tastes like soap
 +    - "The minor allele is most common in central/southern Asia and western Europe, and least common in African with the Americas in between."
  
  
lab_1.1492112635.txt.gz ยท Last modified: 2017/04/13 13:43 by scott