******************************************************************* * Genome-wide Complex Trait Analysis (GCTA) * version 1.92.0 beta2 * (C) 2010-2018, The University of Queensland * Please report bugs to: Jian Yang ******************************************************************* Analysis started at 14:33:08 UTC on Tue Mar 05 2019. Hostname: workshop-11 Accepted options: --grm mydata_allSNPs --pheno mydata.phen --mpheno 1 --reml --out trait1_without_relatives --grm-cutoff0.05 Note: the program will be running on 4 threads. Reading IDs of the GRM from [mydata_allSNPs.grm.id]. 6000 IDs read from [mydata_allSNPs.grm.id]. Reading the GRM from [mydata_allSNPs.grm.bin]. GRM for 6000 individuals are included from [mydata_allSNPs.grm.bin]. Reading phenotypes from [mydata.phen]. There are 2 traits specified in the file [mydata.phen]. Trait #1 is included for analysis. Non-missing phenotypes of 6000 individuals are included from [mydata.phen]. Pruning the GRM with a cutoff of 0.05 ... After pruning the GRM, there are 4808 individuals (1192 individuals removed). 4808 individuals are in common in these files. Performing REML analysis ... (Note: may take hours depending on sample size). 4808 observations, 1 fixed effect(s), and 2 variance component(s)(including residual variance). Calculating prior values of variance components by EM-REML ... Updated prior values: 0.487519 0.535465 logL: -2370.42 Running AI-REML algorithm ... Iter. logL V(G) V(e) 1 -2355.90 0.41109 0.59082 2 -2337.22 0.36016 0.63191 3 -2328.18 0.32588 0.66170 4 -2323.86 0.30267 0.68291 5 -2321.81 0.28689 0.69782 6 -2320.84 0.27615 0.70822 7 -2320.38 0.25297 0.73102 8 -2319.98 0.25307 0.73126 9 -2319.98 0.25307 0.73126 10 -2319.98 0.25307 0.73126 Log-likelihood ratio converged. Calculating the logLikelihood for the reduced model ... (variance component 1 is dropped from the model) Calculating prior values of variance components by EM-REML ... Updated prior values: 0.98443 logL: -2370.01911 Running AI-REML algorithm ... Iter. logL V(e) 1 -2370.02 0.98443 Log-likelihood ratio converged. Summary result of REML analysis: Source Variance SE V(G) 0.253065 0.027906 V(e) 0.731259 0.027626 Vp 0.984324 0.020507 V(G)/Vp 0.257096 0.026772 Sampling variance/covariance of the estimates of variance components: 7.787418e-04 -5.607051e-04 -5.607051e-04 7.631864e-04 Summary result of REML analysis has been saved in the file [trait1_without_relatives.hsq]. Analysis finished at 14:39:22 UTC on Tue Mar 05 2019 Computational time: 6 minutes 13 second(s).